Challenge
A manufacturer of laboratory diagnostic equipment needed a system to precisely handle, mix, and process biological fluid samples for automated analysis. The system needed to manage multiple fluid types, prevent cross-contamination, and maintain sample integrity throughout the analysis process.
Technical Hurdles
- Managing multiple fluid paths with minimal dead space
- Preventing cross-contamination between samples
- Ensuring precise dispensing volumes across different fluid types
- Developing self-cleaning capabilities for system longevity
- Creating a system compatible with various biological media
Approach
- Fluidic architecture design: Engineers created a comprehensive fluid path model optimized for performance and cleanability
- Valve and pump selection: Specialized components were identified for precision and chemical compatibility
- Materials compatibility testing: Materials were evaluated for biological compatibility and resistance to cleaning agents
- Control system integration: Automated sequencing systems were developed to optimize fluid handling operations
- Verification protocol development: Rigorous testing methods validated system performance across various fluid types
Outcome
The resulting liquid media handling system delivered exceptional accuracy in dispensing volumes as small as 10 microliters while maintaining sample integrity throughout the process. The design incorporated automated cleaning cycles and minimized dead volumes to prevent cross-contamination. The modular architecture simplified manufacturing and maintenance while allowing for future expansion.
By methodically addressing the challenges of biological fluid handling, the engineering team created a solution that enhanced laboratory diagnostic capabilities and throughput.